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Anti-Drug Industry Media Firestorm: Unscientific, Dishonest, Dangerous

Posted on February 7, 2018November 29, 2019 By Ray Hanania No Comments on Anti-Drug Industry Media Firestorm: Unscientific, Dishonest, Dangerous
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Anti-Drug Industry Media Firestorm: Unscientific, Dishonest, Dangerous

Guest columnists Sandip Shah and Helen Shao argue that drug companies are being unfairly criticized, that development of drugs costs far more than media claims. Drug research is expensive

By Sandip Shah and Helen Shao

Have drug companies been lying about their development costs to justify high prices?

You’d be forgiven for thinking so, given the media’s portrayal of a new study published in the prestigious journal JAMA Internal Medicine. The study reaches a shocking conclusion — it costs just $648 million to develop a cancer drug. The prevailing estimate, from Tufts University, is $2.7 billion.

Reporters are grossly misrepresenting the study’s findings. The study, authored by Vinay Prasad and Sham Mailankody, focuses on a small handful of companies pursuing unusual lines of research that are not representative of the overall drug industry.

The authors looked at 10 publicly traded drug companies that won their first-ever FDA approvals between 2006 and 2015. Each company funneled all of their money and manpower into creating one successful drug.

The 10 companies did have a few experimental drugs fail in clinical trials before winning FDA approval for their first medicines. But even when counting these failures, the companies studied enjoyed a clinical trial success rate of 23 percent. This is a much higher success rate than the average company that’s researching multiple drugs — and sees many of those drugs fail.

Just as it’s unreasonable to extrapolate conclusions from research on dolphins to all mammals, it’s irresponsible to take findings about cancer drugs and apply them to all drugs.

Oncology drugs often have cheaper clinical trials than other drugs. That’s because many cancer drugs can win FDA approval after going through only two phases of clinical trials on a few hundred participants. Other drugs must go through three phases of testing on thousands of participants.

The authors of the study even acknowledge the limitations posed by the companies they considered, stating that their results “cannot be extrapolated to other sectors.”

Even among companies focused on cancer research, these 10 companies weren’t remotely representative.

Between 1998 and 2014, only seven of the 103 melanoma drugs that entered clinical trials earned FDA approval. Ten out of 177 lung cancer drugs made it through the approval process. Just three out of 78 brain cancer drugs did, a 96 percent failure rate.

The study also doesn’t account for billions of dollars in research spending at firms that fail to produce an FDA-approved medicine.

Those failures, while awful news for biotech investors, help advance scientific progress.

Just consider the fight against Hepatitis C, a virus that can cause liver cancer, liver failure, and death. From 1998 to 2014, 87 percent of experimental hepatitis C drugs — 77 out of 89 — failed in clinical trials. But with each setback and each tiny step forward, researchers refined their approaches.

Eventually, they produced cures for hepatitis C.

Willfully or not, the study’s authors distorted the true costs of drug development by analyzing a selective sample of drugs. Patients can only hope that policymakers don’t respond to the supposedly damning findings by implementing research-stifling regulations.

Sandip Shah is the founder and president of Market Access Solutions, a global market access consultancy, where he develops strategies to optimize patient access to life-changing therapies. Helen Shao is an analyst in the same company.

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Ray Hanania
Ray Hanania
Ray Hanania is an award-winning opinion columnist, author & former Chicago City Hall reporter (1977-1992). A veteran who served during the Vietnam War and the recipient of four SPJ Peter Lisagor Awards for column writing, Hanania writes weekly opinion columns on mainstream American & Chicagoland topics for the Southwest News-Herald, Des Plaines Valley News, the Regional News, The Reporter Newspapers, and Suburban Chicagoland.  

His award winning columns can be found at www.HANANIA.COM Subscribe FREE today

Hanania also writes about Middle East issues for the Arab News, and The Arab Daily News criticizing government policies in the Israeli-Palestinian conflict.

Hanania was named "Best Ethnic American Columnist" by the New America Media in November 2007, and is the 2009 recipient of the SPJ National Sigma Delta Chi Award for column writing.

Email Ray Hanania at [email protected].

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